of ACTH in adrenal cortex estimated according to the caspase-3 level and on the rate of DNA fragmentation depends on activation of protein kinase C. The reactivity of human adrenal tumors depends on influence of N-acyletanolamines mixture in different types of tumors. It was shown that DNA fragmentation, as a final event of apoptosis, is significantly increased in tumor aldosteroma tissue in comparison with adjacent normal tissue.
Some interactions and transregulation influences between different second messenger systems, which mediate intracellular signal transduction of agonists andprovide functional activity of adrenocortical cells are discussed.
Key words:
adrenal cortex, messenger mechanisms of adrenocortical cells, corticotropin, potassium ions, estrogens, N-acylethanolamines, protein kinases, transcriptional factors.
8-09-2015, 19:29